molecular biology of memory

679 Readers. /Width 1590 8�`�θH'�1��! Tim Tully 1 Nature Neuroscience volume 1, pages 543 – 545 (1998)Cite this article. /Type /Font 16 0 obj >> /Filter [ /ASCII85Decode /FlateDecode ] DOI: 10.1186/1756-6606-5-14. endobj It manifests through an increased probability of primed cells to engage in target gene expression. Procedural memory. endobj 19 0 obj Molecular Basis of Memory . Researchers at the University of Basel have discovered a molecular mechanism that plays a central role in intact long-term memory. /H /I << /Subtype /Type1 They shed new light on the fundamental biology of memory … %PDF-1.4 %���� 3 0 obj They shed new light on the fundamental biology of … ;UGe9V]o9@^ht)oF5_T?L+FPkdorrMd6rpWZ!s8k-4hA9U[8V!dbHG!0memZ]8&-E0><15X"1__:$#opb\(; ?ZCL*4DDBRl9XC^3a>77Ms+VkO40%?%=aiZ=?k_lbp"^;6g`J>6rk0#V;Ld#9Y%uojU7>nDUAfFo5d@gU[7i;Itr;.nE?mVLMM."1mc$mn\>_BIq49fJOOj'>?05EV-pJ:K288l-1]b\;(7/jE$"#OCkFIXdprA5P#``8"kMfV-\=L#Ig=$62=oG!d;6=8rn>*1*3og,oMI7H"B'65XI*U^eTc&mp)2_X!D`TW*fA,5RMH&nPrK]Kj8"m;33]c)8if=R=KIbDe\0QLup?kdGEFplstMd3RSE1UP`E"-KAI"6U0r6NQd5-&k]KVDh>^6,g_fETL4:6foie@@$9S\K?20A4%&X\=2b1pl?/R\.;i2_GAFPF"f*,:1o3JPFM.?,U&AT:JB'1)btk;54sZKZtp9Dgb3^?YPJT<6ZchokXLET3*O"_b6)ERJ";TkkTp/'?fM8Uhi63dFZ=(2f9NWN]u1:tAYEJ8@$fP;PbZFk2-Z-[[=o8lk"f\%Zi$Q=7/F:PEM%gJko>A\GFF*/clCM[aIR'Q-Io*!%&(_N"OfJ212UY\?`=XcogTiZ&Gf$FH"MOpNTs8')"3+HAG/n4qaTYc`OsNaUot-Gf[`f&&mA23ZoV0H&K0/e%`:)f>J^6d@OKoYDe7RI0NhH&qVN-ZR:cEW^MC[,(="::EcG>%#lb2@>D;@:-9?pB3Nr/Wh$htY=2J]nF'O9:RK&rRNb/N\,#BSN^t^5!e,@?1b-\ZMSUct:hd=d3)+SBC7:\3FM?lt@d7d+u5,Jk%5O"=f!6q)0AQ(.195M/60?+Z!&r((Ag*`jN0@k]M%Uq3CfMLZ+.?*M%hkI\QtQ"V=SKJAa+Us+mh465Gk3[lIns+>2FXTKm$[rTaamBEC=adr7lNg3JIbPpVTSELIMC`pdnJfeYWDXQgV$_=ks*_?R^"RTu5E9Um54X7)UIjdQl",Jp;/'@@3B9_DquL%EMKkg^O)p9?7Q:F-kNp&Th:%VlKU\nXV'&6d/i.Aod&]2/U$H4+.rXS3\j`m$.Su6>eNoik^Uqe:aOTKbq(bhn]>#h!P927EK"IWtD7!.HUsTiuXG[.Wa=Nc,B,7psXfja@*)::BhsUF%AT!hlQHGnGT?aXmkdqWeUM(M>:)+B@*h(@S2O"/.A"_nB46/BVqc*QiDcaS?\JM_mAu,'2'BQ3CYlKqJ;;\/qBY/^(L,WC]'XFH3cb1Bqn1+E+>)$`*5WVmh?)dQDD3n#d#T##/X'0PWJ4*0B8LU.Usd.$6Uc-]L;"ptj=TT"eAopdgL[9U89p4h!U,D9^)gFr?>]:TXPGqoB\A5ogCe)`7cs.ULk$lM58gYk#Y_&Bks/AI:GthqVTscFn2*j]V?$c.Kon)IcBq'foq/ck'[dM:MH`YI))JtI3nF?2IjStWNCmX]c[2*,Pc`;k"C6^Ie<=,`=a^"Df-t:_R?HLGGE6/pTbJS,'=)7.QIoTh"O#:FqXZ>#hkQ@kT+3kUb.CA]K4`Den*Y\E^^'"`T?Ym;chjo_n[!^(k478TH8YRh'XXs@;)j/QOZPqND#DMn$*Qt\hr%%=*f#S8^;X\&*/i/Yl\U:VOR8rR=m%gemM@NnnLc[&I:M"%Q3-7TFr\-VKKi[pCo!>qk_^P+Zpc:AFk9""?VE%9"%hL5$qk&lRXUN\Lhuc/%XPn4gQK54\&8>=q_u>']%';n!sZbrK)MZ>G*Yc1b!Kgd>s(C$%;?f0Xt8"==p&YFX_gA]-4OBR`S%GrZInE>cMS)T`&]bO`eZGbH=?.Z1T'`h61ZU2%;37rTBtoC`n1l*_ga!kU1Plf+PnSOLmRa-#)t/!6F8.FEBr#bAGI,31H,bCT^e?h.XutV>/)`RCQbU;j;$+X/&NQSc&r>3PI5"buGM#R%!a)gCO%BFXL!)Rf(%i9s&tNVBB-#7:CD8`g4&nJ>iCAeihlB,XUu'b0p2AlsSj@@J;hu>iIJ_2fmhA=]ebQ\`sf#"!P^M.FGerGW!el'.2=;T5PPe3k[VZ_W)d7PmpR\d6@"1T[NFK5%6k\6^]MJUI)c[WG\uak0J_&l[UYV0p"fE3@!g-8$FY3^'W[)H3_\T]QIdHO1H56[bKect^Ror1jqkc.bTQ+$;#R-[1Sc)U0gf[!DB7$^`_lA3qU,GGdcUG"]Y4k^&;Z;.C3db\[&Fjo>K6AgNc->b?e6+r$U`,eNkLju"G-jtRgPIqJ)Q%,e3UY#eg5#<95k\War##g%f'i"fbPK*8tc*R_G"Kf2T%aKLu>gM@C-0J87.=)b`A,]f5M5fINLEIf.LtdB-9@A>>-(==g_uaqk.AR?$_t7d[FInP>;pg",f3>AmYSk0h$FK_XHT&QqoK'9*%(X,^mDTsE^$15XFhjcuPfA6n3`c7PJF'$C+FMsd+XXA9;6Kj\%]1sZP_N$efTC1c*CYBR/h%l5k+,JiHJKOB)f4VDK]=3C-0k//sW_Eg#lEG>Dt2i6["*$%\"JI-\8'WS])n+g&9f%a)-(HAM8<1iqC:A1*ZIK'%X_fFAh:;fll),c]uDLi-Rq01m^Y.F)(c^?\7\?u.]Z/GVQ`oDc(#e08(NGq[++=D9RdNND<3/@Vlg04@):?3OBF^j`#5LeK=#(8!r>$/3G_sVX682la.C3%6TtN2U\$\!\Ed?35ZI-k6OKs70UBrj2a-maBqFccQ$e_"j4;f*Mq&gi!mQ,Qf7V2+8A2lAc&Lgsg3Dto?2\qdH2-]m65iqY#Oa+g:b+bV+_KfqL>+XNGr_$%+_Jp.+0/GPYjA1-,JSo>57lSMQba"@6[UcL,c:i7/I4c*h]5OeOjK9JHF6dcHH@jN_&6PA_/*_-?2%f)!N*.n="Eb_''[3TNDL$Z;oLm9"$G:$_Mo^gWqI0jET%gV6qd2pK%if'*Q6ZWW@@Q0m0E_-I+0J)uZlL2#$i[%#L6Pkq$QkjH_Y`8i>&"EnB(H9^5TFnVeCjaB^f9:D/dbm+l0?iV&j1UJNeudm24fGmh^-kBa.n![J+[#4O**E%!k'#6\)\il;4o5us/fA/Bp=G"f5H&@gPC]3;gb]>AB]Z0%-'Ggi:qbD*2i(e2B>St[Vfh7I$Q45!$1754jK9i"Fqr$rV22rC.Go/UV%t:dg2LbN??Ad@"l$8r&XrQnRA;l2Zh@l=cV3"E.XWEnEA-M&lHs6Lc%R[k^l5]UdWr)bd.<7.7X&30XY@VdnU#:%W*M=808D*&,?h)E7Nm!HTjfJn'5Eh;R]:Jcj3XK!k\c((RKm.\7I\eR6jMT(-lruh[\kf\6Tm[KHam?.=]ms?ckt$%A,+=q*LC!Ijbm0NL8_sO=&=roK%d&Aa8S59M,kb80I`uCV'NrmI!I]Qj8SWHXbZl^,32akLIXfReBaE2CFdW!o'%;+nD?ID%MGu*A'le4Ro#fi%W)gC[WoUg$WNR]TK8rS4ObFsAhTlo+s1_M(:tkZ9AP4E0Z5lW&kcullZN[@Y[lQ8"J0o/+@jS)em@*9fsc]$J.sC46^V$)@N:pupYAS$0%qg,g@iAP^h[k`"hE?L,+\co7CMB-hAC8on6uAq#cKE2RUX'i;6Z0pkNS0mia(]:==dSr+ebc6YkVe5%Ro:k:Yo[P!Tb9GQgro%GF$qUG;e6E@,7O/c(emlN9.!#5sl0`S^1hik+O9]\!lf"Ic3BL"7$,1c^/$=MCPR,V%G^=8<>i4+c(TK(V0Y,;;DTXEQB@b&8&V0.>QjP&NL5#AS#Y.eS^lTXB>(W`B]UL^'W9M^a^Y7eLo;4mjnZ]j/^%Srra#Kf5]WX,+^6/7kR8PLaIeoc!*j4g4"3,EgqAkA@mJV6r\8q(QfrraU'Ji=,78N54-XP:6$V>f%hku^_)bY:*+jDg9'Qan7@7K=QFC/oaW-@:'^ugQO#>s=Alfb2H0^@oX.amG*#nbr*lXB=g?7(5Bf@^+ub,[B)TnJ/2h=!3u;2%TbS+2L]7Dt@C(Xh;>G#e1TWR]gdHaN-[Tf;K#6$M8>PmjrS9ZUHnJK+'Bm[dLi,Ej`m=)dKl$hFFYX-VWY,B(d]jLdSQ#!!>e:c7\6qU,>b`\317m7[jD6EH]IE@Xn@"'sG%9sCCcRZV+^Ys=&YVe\O,pDq,)Ts)B]:G"Y9.RibsC*&q_V(5-:M2@+C;_QNdHA)+M]6"4\U\O>jMG62>"Js8'$KbA@HRVP>qd+dge7H$iJGm\9J:3_GNPM2pZn:!)>lRf#$+$OL0b'-<7a&GJ@qmrfp2IWkRMKh5T"XV25?Bf$V_)'mM6nIhO&LSRC$f=p4'Ws.P+!O!:D(T"chAY]4G)ST?53pCP2d0CWh1XoGWqG:((H6UOd31o`>5YW=R8uB1P?7E9V4Qla(%W-N:.Ep/UebbKOMZk8l\i=W);:t-l_/\5LE7Bdip_eIXO"/LQC1qSt&E;3-h=o&<4uY8S2:,lBW^JU@FHU!$;251VKRK9)B6SVH/HKW[Od;&6NoM/@'l8LY`bJXY6(n$.n8HC?mVRijgnKS2hP7f(*5oBnY3lo>\Bmc(0>=;Ts:$acD`aYt;#0,DHA&A2Xu,R4rR4-&QM;mB_8,=4p/OpR4./GmSO^Ms4,sbp#s6m9oa)F[Vad-H,d:0gH=MaB5HmmD;-uBh>I_.pZ:`,:*l0)Wr&Yk90)2^i(DpsY&6hj?+Geig@'TDh?tAn[2"Q/3o:7X%E?;11lQBT!mYlVj<23Zhnh03:YAae*HrFltiLra\3>=DGVe"XmYn&/E(EC4dVd/m;ZrD:Uf*0gQG(;n!U"YlPe8YT!&00,87f43TRG4L;abPhtDo%qpL_O:na`)h"f=m)7rq#4$J,JbR(/X6Y=Nk-#B?0PTR\jAEE5aI[#dA;uFFH"f"Fe>K_Q]fO9MhBk>mnIg`5fQ[4T:Xh*J(misq?5Yqgd@31_T^G&L/6[*@E)M_os8tn@q#(]\-8u(rDXH*V8cju@[DaMJhQJZtDV2N>'[S4mclFjM1DP?7$4to[A0^q9Z0ZC/=6$CV8`%Ir9CV,oYH_RF:KI*h`PAWnNXUG]DVJ!(]N3-'@Y^X-H$Mfh"+M@*j"6(k89`!A5BFmPF@d`LZnXi5!+R^#Y?t,aP3TC(c@5R?62qJra*.6XhNOZrS/O#JGb[*aiB5mG!Ad]=q4CO"o_15:[0J8g2dbr^6B"$m`Pa^m,"LO.`WZ`i/hl_mk6T:9iMAFaSZB9WUj`qFoZ]S%Dj_sp[YjY"o,9AmuXKC&,kg>X3HlA$tW5s"*L=:-4mK/Ij7FB[A`3u$r>(AUhVa@AW9C&+7I*pJ-,^V@C*^"_>Y*5]W#8oHO+>c;\;PENPsTe64.=q^p):"snTRDhBZ%PD(+tU35e/Wn6JTi/oSbfUU!KJ8i-i^/e,B'#1;AB=JJ:fc?S"K1:/g!sAEYd[?*#DkZ*QLs((@VV&]nhp(0LWs]bmgbYk]X_VA>;YN[rknF_UjV(#+XeSQ;,TeHAIOsqQZeE%9$f8E5[)+`F4H9=f%W(5u4paehe$Vk+JEMB"Jp@Abcuj.?r^@=OeXca$*T6j'5:"m02P)a&B@MHfN;bL/h?_t-`JBbsSN)3@?_)cs#[cI#NI7C0:TNbomG\;E\S3"Aqe9-+=\0scZk*_(b6aL.VOKSO8n,35)STf;VI1`K4os*E(i4GW8M2Z6*0IYt@Gkda$RLI>ggc@SU9`HU/k!U>Q+4D6ek8\up_J9DKdW;CKK/k_YT(lj`-7gWM$.B,f%=Z%pG2X*M_r7H:5@l8LMJ&%c/N-Gm4/\=fb3]ce(jTN[2iFHS[I->q0tG8\XUoL=rPt:;(0>*dj)4sb^m1"s9XVb7/XT@`%;m?I`FZIe-2]9bdY9B3JSjf$SQX++3cpIO?Z'7LLbi/)PW2O_u>)!1*p,N774?GbnE6u+3QDjQT'mDeY@GqqOb02,m%d$5$`J)IjAh)fG2Q><9^$.4EZ6hQ2fF%kd0mcG7g,Jd$aF\o7r]:F=19K5_MT#2gY!V#L;%'OCaQaOTgUu0eYNX5>J`d-;G\?F@Q;(bMVPY],?P2j:]h&iJ-Z/M?!=L-U2QBdEe_=DQ!1?BWJB@(b::$1WPij_bP!Eo18?6M[rIQC4.Vn+)]GT6QUeH:`'N7]1/p[NmUgLW&\ke!HBX/)73F6=[crNB7p'WGa9l=hdc`SF(!*s!1<=e-J]795@;T.K]E.H$S_6'5lYB93#-P(ML6Tg2$B_?Wh(N_$Ss)D?nVl$-H`L//SpMk/ZaYqBpXAd`/FSi10P3lEs%pgo2VEO8EH^cAj]NU_rKa'c7mR@Q]:FEMY^k71:2P&BL!pJ>hN/YiNCD]m)F--L-5bd6)gn)'du.]l0o-a%JRMIV5,WjA1bnekQ1X\Q='Xt_-JqFZBj4Kp[.5/b,+2t^254VY,<4`R9:2kjN&.^O4O(1OC^Gk.fbuTG/X?;%O2ME6>XNHnCV3F@,ST%$fK#89g6!U*F86DS4QS#14mXN@1:E!"W@3X-ccOT3T]Ig/57L%80jKOg-:fusL(TWd*ZHYRJI5.%CYtlm.^Q3lbBR-2*8/J>Y>.[=0k15ds&$,@dCZBCVmAoIRO$eg-2n@9Pe0lqb$U?;L-+n>Qf5%&T@_(JG,mq:jF4&3WeU!6>;%pn>Hadp./hm=`!R#Xf0Kf0p2j/BDPLt5XVPb!_h;0uT-[QjbYSb#"1@RYV6`.sfcpdi%YU+!?"`'9F][^g.0aU_p-Q9EV0LHA0=Tnc4mnpH_Q"&kPZ)bZ(Vo[d27=SsJCQM'=rRG")Nd-)rd%s@cbd%G`3(XMlG1t]?k^@-!B6/c5kqQr4G3kt%lHNeL:VeuIbj4I1[,S=6eT!-&9,*h&YiP,0fj,p#M'R"Ru*U9%F)B:PN:X?6rK0!5ph;YQn]#2#2N%(JqO%@+hXD)d+sk2b8%rRGAX[\*ph8;h3?!_k'LSR>(/g*(pchMV-uQRL2_a!6fW51;lf]K`Td,Jrb?4Z=nPIPaDsi&kV;q`;V,qXZ&MOgbWQl5e:oQ[at&3p+pBpA'^s!R1A`9,'0?Onq_at+l]Gg7c!UL;LJ-9)?1:,$t+P$fU;X88J*g=3[&W^,Pu1^R&>:r.MR?d4Y,KdVK&F&f>e0[jl*kuC.`9NS&S[=igtHiEAAD"L7sd,uW"[XV3SA;35etZM\Nki`/%%([Cmo,7#j/7;kGfo-!m27#KV+OE[CBHJkMJ+Kt4]iV's%OhXjI&)h(CRrFlqBJT!F%dEkcJs#Fb&,55qSuJLnaGjHmNfnh',C@p:UT*=:*E1$EBXc'KG2rd(;_rGOErrk2g@RB?l&.IRr\Z9c;AqmR)lnlLZ0ihY0=El;'%;e[^'jr]N3MVYqG'GI@>jgfS6(_9!smN*hcg[Dp(;C6`707WD;4nQiKA9[%jt0[3)u&q*["YahbU&C77Jn&q*(AmONlR:ntYaC).AUo8KL[;(f&$`fmg[u0SA2A%@7Bf"qOk<>C66GuD?p1HH]Q/&e0CA2iM=e.7Cm,0*N>o`bSASUNVirs9lPd??_pX3kqZ'4Ob3BD&_hV4*V#/\kd@!g7kC1(^oE0F06\p$am9PMjTn@GTD=d(9H>=0%)YrIM\12'4KfIpls@>c,=PMGR(,=pVTJ#Ud*p1e:``e,`K_=^c\Lh`Zf[Qs$GuAA/cUKg/"B&S==/ojBs9@ILch[:Eo3mZ8Q7;5]`\p+&n:`Ya!5t>=%dI2*0W"?kjP5*aWmR?%1NCi_Gr>:7^Y/nU:E;>*`AqL6L+l^saI-%b1\QpcSFR("8[9d=;Hhhm#Y"@TD-Z=[]6I'$X'&AljKieQ*gN)"Jc(MbJ3ZLu7H,;4ogB/^@aG6c)A.s(2--?tFH*rS=V]4C!$$33(LqrS63G$]dpAJdB;WGt](:Aj@3(@LP7/l(E\@g=7ej"`QO>JEkS`eY;V:HFr#.foM9g!,IBNRD[,Ff;B7@iQ#p2MU(q-=2$r]'+-8k;1*XZQN:XuU\]L#@C=qZ]eNW>lpptJZ$sT8@je'JNr/q6p8AS&q`QB4g4iiGGGUfjnE%Q=3#Ef5%W40q-A4fq6>X\/]sY3!l=P#*kX#cXH[G5efb@V^u];iVog2^iB>lrRiYZ:lFR+@2>Y;oX7.PPpB-#QE^0'^p6Q:1oh6F*&Oe>Z-OUm_o"gD8QLP\Id`&q"6aW@"f'BE&l$i6kh1$^Q0;jW[niLsPHDn);ltV:C:#H>9cRbG$8E:8(Gl#.NpT$46V1Qat[5Kmu:2*Q8d%'@tpi\cr4M>VN:4C!sU]:cb::s*Jm$gJ)Q*%q@Tk?((AXrBZHDj3ARP(i,=C24u@I=B.HpW`'&,0sXpla2Ka`NVE*Mi_,A;s`=Qn4;5S;%kIu=72sKK>-Zl22+a4YUm^h[UJ^f0it4o=e&ogco*$JQ,ahjlcjt*H;3WX(H]rho;RpjCUn=T^6As?KIYf*$ZR!fa0(/-,*"F?l%*dI1JZe:ni.dAX8aO2A@",Kb=qL_\_FK,%=Y-F$gtFReGWY)q_#,Ap2#!YhpDK^)Z_d>2>M"9Bbbks1Rus/sZu,e^`+Xd&hOQ*f$0[n%_4,?/mJ%E`1H`esq@s7W/N6IAe9Kb?0fW>jOE%X]W$Eh-ZBc]YfLW$h)"VEtLf(?#\E5KXOFmeCM`7,J2_k')H#k=o3Rtg7V2IQ/R]k0_J]Qu/^tl"'G1BlZ)3f@13ir*d`j;OK!Yn9i)H(pO-<>[tbW.4a9k:`=_[b]tr?+&Vg5Y;CDSpLY/o1R6-&g4nLMBhl6#pf1SSSa$C?q8uY&GqWu1i]b2uS`FkFJVCQVG^QDHSpaZ'?W8lTdSQI+#XYOLip?$T*L_i"Qse18X:_>KkLA(3%*;?^-f'lU=[Cq!l)1\%>oPH/X$0_7,:^9L-uK"O>Gk?d]mVK!1piR&H0:>""?d,Gg9/4=W%6Xn5*L(1oKJdh7fOp8Rn3!\)d*V`lKG5n=%80M>gHdQg$WNL[B[k)PGT(g&9OR_1O`0-ULu*%PG@G=1rEpApU-VD$5PptSTeA-7SG=GCWmsAc7LGP02N9%R-ZbFg8V%nb=j0riL36(Gm*h81f:/X.d?/k21k#^AR8iKFBR.Qn;ppXk2NtN$&).,%7@(&J;Uh$pk*K1r/BMP:A%1Big5rL+*#"Ecf*#,SQ^YR7tXHd(--Cd&P6[fhMQ%G/t(o/:^O@b2[C?iu@OW2c+#Rh`bBO-H!iOhA1XGG&Ir0Fs-$^SmEe[YPX\++8$AX1Fnpko^T[G%6c>M5$d[-Nqf(`[MR6MQDXGE#2-Etl+UA"$("elpumm5NV@V7s0!B=bTFWh,tC(OXhMN0erD-D\[.PlbO2aBH#RY_&G+D2N'R:hcl?G![L9?="^[:=`1OePK@LTA+>DU5"=\e52)fOq7K$A^6i7ZTq;cn@o\'I(Xgb\.]VUi@O%WCG//-g-sh=Af=+D)>4&N=9\QkOQEN/]pNfg@WcsVp.!*8c,#>=7"-b>;Sjo*6CkBR*s0;.OmlV].hJ*h]bBJCbM_.Lh5M25W(!pI[oC/"=7+7n:KnPGA[E`g@5&lB2doq.\9pB[.JF'9q+@mNLW6gTDpTXJ<6Fg+PkdUfl(@S2Gi#!;+_7VY@?QS^hAW/q]STN%7*;LQKrB,+/gGj_]%4e=*?Ccg$L&hAXU3'"_Je4m@tcYD,7Fd+ZP3K#*W8AA5:9*tt2B:64&`80e=p2jH71mS.!-G1mRcm+]X'?PjGu_8Z3POpd%Yj$nKYYHqZ>Z/#nAMuP"+QV`0i]T[MPV)PB"+mJ@^2j*AG%F-sk>"p^8#2"'tPid;k4AhlGId@N\/L19,SQ%FcE2A+bhs'=2=c-BY,hbTM9?2FXWJU)Rn>9Me)G'Yk;'hRK'$Z\38$Kn_Y7!jN`MDJQs]MEY(>?NBs@>Vj!$?RuBLA&t$im.VAkgSiW1ml[ksQ*_419%8I*eX;S9sC8Z-hN32?1K)c>cNM)&IkZ'+Zc;$0BN?^$RMb?[;@TQ\puWi5^9a5q8Aej"O-WGLgY:q_Lk1"gQL!``/9a%dQ+_6WcAfOET2jgi2[RX=j@@_fl9/OFRd]$7ME4^c6q/*&db6.c))Wm>sCh!]k'XE)arfRPT#^i:5j?cot"[ULW^H7=TL+L'kihmKRYYU+s]E4&/EI)&HR+u1l3#]#$s]r0/]\p!Z.:k<9)JZ2RI5"6"X=2q^.5^a@aY$>rU?bh;,*JOgD979^#P7l:lhR@!N->S#5=3?)srX?R.KZ;Mf9hdJN%+'+ZM-;EMM)%Z$G0HEIC2L4U=$ek>E6#eG4)!qO^_4N9'jue%W@_Prh!XIK6e@6Gke:Uo?3ari+.[D]=-aXa"G`K@,f+@a>_sE>Z%bDZK%WG"K'J4>_&26m(0BN'B!J[_].?j\+9Me_SbhlWF#l"aOB3]+37$!t$1#WZOr68k^GFDXihn9PT54&_YZ@=t"$0El6U!DpEK'j&5EdB>o?U`Jstiqd==)oMKG8T>'Y6\#hL:$=*1i)>7Cq$"WJVj;t-,V\-!Y$Y;u]YOK._`6`:[*I=p4JZaqAX/`n=1XIFCj8uf@"D7O/-PXtZ.kWr:XGq(l.[,_d]gm@#m."L,cIiKFM$;G@7u-dYOS?+Mr]jBo+SFo;:A3f.[G:#n!3S3c$/&KMR]c-hN%f58A5sHW]F[AFhDX*E@n0"sm,[qCINTmJ3P[MP^cMIA&IK"j@0JSgmRZguC.,3n[#B6M9kLgMneYT#d/siRG_R&m;G/G6C8o+ghTtK(qg*VO4`:\L_]Cq_\,U];`[/_$\FD`NMeg6l9:lK,gBU&-H'hOgY@O^e8F`!]G]f@g0Gr)^eV7k/kYk'&>'IURbd,C?+:@o[8G/S/.YY'H#A(ab$rIJT+03hkYSQ&&-3-NnD@"dHKC8^ghUR-7(%^QEi&)=&F>6d%mo=A['Tta7Mb0cg=f5653&5JQ%eK0B;8Elgp"uE.%GF41a2I*?>WR_k+CGbejHd"'Do0@"m0,iP=f(F?s-iKFYN$6^#.$CF5pF^KbWP.$1JdkVHXpTDrp^tF+0.toF3:g.`-Ym`UkbQ5BO794ME[%SfpuaDU+^(p7qIGU_aH&WDOG4hs*0I&uY?0=:0*MW4k!%^O$%Xs"Tj2$4^jUZXoVeY,PH/A_.3\V,6A#8^8gNV/-k"6#e-?XIh713(WLTWs(Yb8?HX%Ws?CB$hjP1B]4Q[XF=k,c(0Z_+3o.F_uF@=>6];UDgohc^F"i<7\3j981QT4Q^$n#W5`7&8>\5T=9`!)h.3pP%?bni.hbXDl[K#pFk-ed&ZDaAFKcQ(j+oW2A?2+a";+k/p*+BW6TXdTjf[Nl0Wq-$;\oVY0+h[C?:??Z,_0WdU!nGcMDm?!th(EAe:3q#10620#Ndj\HRlO&7l/0Af.`S_?;#N6I7RB9:6a&7k5sd"#!iD_WGS/q)NtJH4%Z,IpIUOag9,pa\SF-uW7N1_-4uXeT?nOoSE=,`D>/qK)kc`3o(hM;mVFoP"=oGSR5S#?-4mfGHnZV)'^6#Lh7X")j]NU/FoUuaeDTd\RmoIk^*STjA#/8;fKkkNm1K-"M?%'Db(Y"orH:V-P9N'!9/g7bY\FXdG8e]",_r$:e'+8E&$q6PiLCPYt]Eh_s8SK]-p.#S_ROSCks,*Qib`S0o8g`B[=4mJ$:_n,ZfsE^,$Y`V4o)ZGs%b6iB-DIML&H/EPT2atN0q`[ii1;:5]i-l'-\?-"SFm#Tm3`&65j:`a=PmMH@8i*QFL?mF1Ie-h/FK-oR'.F]@WQ5O0m1fFmkZSAMYoY`#LoObZTqsq@b$WVs6pU_*H?d)kA7:F:/:jmJfQ^^I7`XE16DjQG$%`s>04t?0]D(o_C5NSkC>JZVR/tJ5cF%dr3%/igoAd*W'UeH20`uKu6i"XgP'5[-["$ILu^l?:0ihn2,/@anC((\,WGpWWq8F:\[;^TFK?7rQV=gJJ'!/F&/^,V3o/aJ$ObRu:ID:TRAaoihK>>9]NJ=bXo!dCn)a!R_ho]"VDrp`.4JUr>Ye8tAr@bS0oWp]:f&;\qJO"REgQ/F#65thVg[oIUZ(B$>nAu4[T(uZ;\U=QM\7UR#f>dj;RFmTOGDKRR:LD!92j2O"#-OOe5lHQ%=f)NsiZej)4WIkVsqGhG*K,Ye"fYf8"D@.7;!5S2Ihc"rJ3El%?MgsjK'UpE98D)hiEEl@A::oM!6#.PE+9]6N.\l@K4Nb2`NU/"ei60/6SQ9A3Xfj3A"CjZ6#V_n=jDTA+o*I7D5\b9L%D0hVf^nn,!lPLiS=Rn5$((E.,h>;phq$6N6@1W=h]=!k-n'm't.p5t[k%K4Wm^N^MN:@^_tV:keJ>3%#@^b6UF&^1.Ikn&C(ATc[4n&rU3H02WS970!]gSnV%qKq-9$=5gSdQN9:trC#l\Q30kPJKd_V8\]gk>kfV_2eeq^G%np_Z_nk*h)faBfIcA>*fo\lXkW&pOh*U!]VC@:Ba+3>q4M^6WDEO,&SIKq0TBJ^6^iB]D7jm"VP_0dHpq=Z%Am9R#T98SQ&DI+",JqBL`Qadg2rcu[n/OR!H=.:aXth/Vj[UA'*do7eRQ?0YaYh1kl],39.^!]6*NFe88Vd5qt(&el3P$j#C0l[1(Br^?tO/Y6`/8u@ZW$DXYFaK+>$%p7+4X.:,7>,V8/`L3\T2,/i_pKS:KeLrZQO5,QqQSnc_MHJM&\J$CQXs?S7'5pnLOd7]'[_b.U7e\$nZ]rA&^4WkRCuG;0;8O4eDmR-oY[$)3*t0uFgrdnl')K.*4Ld*Ir(eknL*+*4?j[Y`5gTMb)CuqpV'iM"ZPdmhjR_'q#=%RtW1b?!@"HAX*_`:7";3A^GS[(4p1SBS\,mK&U>06n'c^$ebRanl'0]MLq52^o)im02W>NFrQbgVS4I*?*Z:ih>eY-DG45Uhm;\M#Z,W/=`C`*NDW3K*2c0EIlPketI/(=>28df9R-S0ueI8$bc9D"0CY/l(?D"AnW[\Q(`JSUr!U38eU(YF6TKBL-/LBP%dOTm\MBp*[U]9S-Qs.2*P/bpaak]9+>/p]g_[`8D=RP,&Wo;Cj$2&e[=]^+rA;o!_2>FMG"jnG%(a@%s;bV!!)^ZMe9\TiF8j\iOI"4nVZZ\k=tI,b(j3DGfso(BqjJ/2]JU2(BEo. /Names 3 0 R :!Kd40S5nL$;'+#PB&Ir(m4bk%F/V'[I/OlT+(pR1H0k-ll3526[/J$/'\LJ%=8l/p8/GL$J"Hd9riFh/@Tqp8XWi-IsdZb5*oaiE3@K"4+_62j&b9l[5-"56q1;!WGRhR/Sg!G'8$'^K$iors(=]oPX~>endstream >> (2003) and previous work. Siwek et al. /Count 23 Langdon PE, Harley CW, McLean JH. /Type /Names /Subtype /Image It manifests through an increased probability of primed cells to engage in target gene expression. A significant symptom includes having nightmares or intrusive memories, which makes understanding the biological mechanisms that trigger a fearful memory all the more important. Biosci Rep (October,2001) Neural networks and REM sleep. Gb"-6?YEHkqY-IPDaK*''#F,C.ceGK?+V.m;5gprVqp"M3c8d3o4$=S$*Db0VWir6kId7R``$mCL-uD$h&r[0I"bm[875drnA^CK,2Sa"GgT>Ab$lr"'U*[2mF[uEft#ZPF3HAZT4cIFr@fX#P;UAtoA:CWoo*N?)?=<>mDD:jB'4[6>nI&:zz:depYJ*Gbc(K'+izz!!%Or9#ltsL+;[l[hnN0Xqq'jPzzq'66=g"TSN&z!!!#K#m.'^rV>2)!E@-6"TSN&z!!!#kkW=!sF73HoT/g=*J1@kLTC9c#zz!!)F<0)sY9pFe0Ar\0ib4_4Un\836._MUPXzz!$FQ1:k]RYRgPeqVbb?j56(Z`z!!!#G&eRAD8W[gDJ-mh+zz!!$K=\%I$&r`N(#bWHd?iDI4-EU%Q5POsdIlYZ\75dg"MBmTk[=RcUrzzE+e]dTUplke9;?aUscs:rjk%;1K)-r#6$)>k%])=Qd39oH0qY`Yb'Q(ERL#A&nTOSb3d0[^7,T4zz@#JcJmFM3AMc5[jMpd;*:8u/;p3d9%slN$tcz!!!#CE,U#EB("p9&!+qh79L7(<7P`3c$,fYLR%s?S'RV/Xf$b+G5[lu4obQ_z!!!#GjOX78Yob%S)ldpZ;Ne?Y^]P(TW]>Terk*^[?>#"M9&I1c*d[kezz+;)I_m2C65;(IKN;sfJ!MF./AC7"g_J1Ul%HG91,V4J;'\^LQZz!!!#7R=!,X(T/>C)lhW#:VD*UFq$PR(o`?$qh!Z#Zth;B@8RUe&;=>PY=#*H:^-(G%Vj1l[];'l?2R*:Odk*k)$c/J>)N?gH=Hn?C48QQm2N(ZLoT0NU_4!,l95*67m.#I"TSN&z!!'dh=aY*l9SkI!Mc5\cXOQi1[D"OTpN60s4g7r9*9n_HD%QeJ)il!Lo[MVohg!aOOAl2[z!!!"a]kHE(`A,?Xu$0',*djGgUXX;3f.VN*X3L\b@cCp[8OmW*]@9^q5kH/sg0g)"0]izzJ:#J?_\_U8ltV:HW@@NI/,QjG7t-O"TSN&z!!'')R6aaXOEU'e@2q>V%rpYVfb1tpo@:nrl^dr>/LI]T=0*n5n"0IA$qF@,S^:Zz!!!#I@*hX8)L/3D<=-TaA`eh?V;?FaCeOTqo&1+g>s>r5ioGjnKAK/,RUl[L#Qo=t:0mIFu"li'MsO$Z_Fzz+O$t`B5ge;6ggp3*]s;ne2MmVf0?];S7Li_H;B%!o7)5N]*eW>z!!!#7JpY\A]*9=RG>nBnWc1mCOF+"PB28C#?iSbAF.WBhh+ECEbD/<0oD>`gcCOXaIfKHKz!!)MF83)B/kkX/bm#=_0.P4rQLAlfLR-NM"^[:jVA++:bCsTO`S>;VNmQ:ILz!!!#o@:nqAqIP*I$!1`1phgH6%kG'AQ^@a*IAfpS9L\'fn%\"kkjR?"^YLYbEd%EuhjjuPzzVjLZ=2tk.aC44?NCI"-'j^6me3RoaLlJ8)I'oW';:OhM4:NaBBQ::IlrVuiop>TB84U8bE(qrhE8#>*0Fn"2r!!!#u_tN%4mfh_t!!()!$O[>(j7$>EP?aW(gqD`sqIP(G3Q7NAq-R;XqHL^an!8fo,+*-"jjP1F%sjRADgq^DJ,\L.oA+$Zr"h%d!!!#9Gh5kJ;uco[HO=5\/l"Q)5?HPt<5l/Wb]/""DX$rDjq1@M5$\:iXl$nFj)@ZPaJ/Ni?,,O6_Z9HB0N8#P!5a!4;_V/N!0DPJDlAV*SO2O>enH!q[=8-^Z,07HVV6:]Yf@?B8!#E!"d/^Sq&l!'n:==&^C!b\)6uK.KEkT!!!#s!Uk=AL'dn\E_e:seXa\B]mEdXcA]1QGX.n]].(NX=6FIE+6namGW,19$m_+A'n92RJtZqV>-64hDKL!->V:d8PUUeDge",3T0GJ%]s+a!]=@olr0&Kq==AG"cgrpMLfpQ0%O:>@_rY^gtGlpWWFBrO^E>UrC8bg[4/UMdNfNu(/HA%2aL\';T6Q5#&l4(D=tMM9BU2UMdo$?XW`lNbNfJ:*FkLt3Aq6QV!14tBL8nEaUZkn'kth&6qnB?I",=`d.f*L2P,d]'O+W(&4Ee6%C].Y>[&o@N`u5@$B]RZ>=j$`7^EcdL0N?tkGeY@_$XfngkGAA9;ucnsACOFUlYGbVU3H(9O1a[!66qI[Z_VpAkAT2;:>^6jFE#0-c4OH_;S&E`cSl[jd)`2[.NL`gUTa6TKW5]?$N(M)(M%18%FsP#A1#n"21p;@!!#r.d885t$et@UHc/N+2]M[34E`\DioW$E`i`\?h(c'`Th8\?ACuO.!f`]g.OlsVRdn,Ws),]#]8ROC.M0Vs"kf;N6aa;.ZubD*lQXFh1o'^!KqKiM9eCeF!a$^hL?d(DoCUf2D*@@gg\(XS=6FIU2u)tjWIcfR3o#5^jfQdEtglqP^>N8'87]h>AE(tFq/PC;W>qX,)r^egFKH3s=RW'DTBL<=`jWg-c4H_YBk(b-*:qZYZ@4%!RAFK/:i1\\Bdoph#mt'mX;EFU>G[tY5Yls,1eXimJ,\#qU^DlSD7b2,:m2&".cVh;Uk59ANVj]p:=H2@Eg_T\'8?kl&apNHB9!C#qNZK*;JCN+gp%cl_pLc&PuatuM]arP:/8gO>MjQ+([AodBWi)b-EcTUV;Eer2/m0fnIFeP]$5fdp_q\)5bWSZba+9f`l(J\dG_!/ps'XJU$$Wb*s'A@YZ#CQ1CL7OtSC)P1\,_9+;V=")1q875!f^G(.YI.8nq+q]JY@=Bp)"/8OB9j!l[[s5H3k)UJ!3?5hbGpYHI."bmA;nUr3STe>SZ(b3nR]7)IigO4S4PkS52.kjpFN;!_.a?AjPKnY5`XtFi[iDD0l651CAWR5X[ZN(>Gphj4k'BQdc!cHVsXCfE)f[YoO,hj'TWF:.p]7)O!CB;Q);U@_C2;ZHs9:_arsL2(>gWKGjL2X^a.M/;SRqVR&PP3U"GP*":Ag`TK^fE``hR]F`AWhYG24pO\&q#01?Ap[8Q@Gg@0JdhKoJ+'=)NTheB+T5(W[mk0N>LtmqVSm^6;B9_GGeJir+Jqb_Vsm9)N2J,/Sh;utm)?lgXqa&I-J/3Z"%j38?U/HOpW1fVa1rVjke^!9bcrmc2J+u-[s$OdaUj7d:&Ktj$=hR;Zoh5I+K/7G/-oh*5@6Ne-m&UVgrt8$)r5HIhn/GgFf*V3'qt=lC6^q?iU""/gh5k1K4g)+ep_j^_n1&(!T*)*N;"X;"pYI^!;INQ=6P5O($5nb6;S>pM(Cr^S*-DbDLV'VW#6>$NN\)W!\PT6Zm2DR?8Bqn(_&)a3mULje-qL$,67C'XiaR??t$\6+K%#PHNG,Tt_"b+Ko","9]_Xl&),IN!p?s?B)cqOhN"4:f!0Z.[>B_('(5I:_asWL5H3#7^<8/H3O'TflhcArk5pVc:9/1LAlfp7VIp3l*#Lm5]\7/*FP7>)Cdrf?8kiBFSjVk&*Tbm7V_S;o_G#$d,G8FJO<9ZfQf51E(E66AW`17RV*io>igHM?T@9dQT]oD>_DO/5(i^cU"tm:M`Q*96F\Vj@'HKqG+,l?R%4GpEO6I6LWhlBTgcA"qSJ-tW>Cbtg;naZ.s-Km,%^\Y+.?)lGTBP);r#fOLK9[o\96R>K"jK]I9UbcR&>So']%UsI!degH2`DFqfgrO^]lh^ZL,2[!e4d%3t-;GHsUqQKP5U9\t%:"=jhB[A(U6%##$SE6gO7sWMo$[St7!p=s29F/M5AoRSEm+YKBuRc:,9KVQ"l*6JA<7Vaj6IeH>UM?!Ub./&GHbDS^hDRA$@UCN+5hjiXA46!'i7UC0^d[mndR,H)5TSo-0l`QV@V?>%:pJ>k@V=Pj@.U9`@RkDPDM&(2X0rH_7hk']7E=`S>WQo%P:+O.TnU6j9sKfZ]up!&2*8G2Ti=QS@83D2f+1eUVTG7CC)-./XDrP)M;cdi(#=\bb_#-pCpCX'e/F17@'UQmlmn5cF>,gQ1pKjak0G;`(b6/kI[TOJ`a26ZqLUkfA!`ind6d+MJBO[3]c!FeRbKhkX%/W#r\fM&p^k:BNt\,apD6T>1/F6dd(NXWFajW[D_c%in.':?`4n]W7*0N@''D_:?3A?k'd3br;Q$Sj0['D:.,loom\pZ]BR=CU2b!+c.#Lcl-$f7[L3Q8B;k5MY7?N@]JhDrP[+WAiX_,1/,'eO\%+Wn=S+M8\>ElMAgYBITTaT(fOIj+lgH34Jl0)YoW"_Z$!iXPB&XT5C5t07]r6QpR@XNRYP+.>N6MbpVgQg:([\6<7G*3anod,:2Tn?NP)=#XHR@9@W4n-6dPlS$VA6Q73s'WcA)-Q8Aq:OQQT@$cpGLMP6@mbBMk)&hUM'B5'Gqr@0EDr"FET!h/)leXn$j(nWe/bb7f]n@P!10)mpp18?T?/m=QlZlKeu/;CoE^XNQRNS-g`CO%mrdhT)?-uE7m0L[CYdeK;#T;+?EEM'ni&%UZJIV]A/72+%U+IcBEC?kPsa3B??#'7+tN['L:RYAGh26PZXlg7=mO[@0:j:W60+\ej(_k46k\"W`=+Q)XG)1tOEZ*rp+Ej17dQNOPh"M+FX`QVXM!W^ZUgbgSmC-5sooe+d_u-eTt%#DVO'eDos;pV"&Q6*[oiSV*US]7/#L&_3'T\Of-*e3MkjdZs4,a[SL8\?^j\UGnAa=mP'&TVs#=B6Z+Osdq9L\%o#ur4nL5K`k@B#]T;EB9V7]`o%D(@Kt)b;IIQ0DgnW"bTnQSON8!Hj]]Ec%tCN@??C7kR@&O>iqn=MVU2jY$!WeH]6cC_paD@OXd]B6RX/A>lK)3.3Um'mG7r`.053$_cTaUSf:][1L(]@JX*MCMC0rKrrlZ]3rX5da@UKW:/;6cJ,lnQ=#g!VaQ$3^S/E?J(4qO1*W^YL*>P)@MAFSVnC)sskHW!lGAjHD"mfFf()D`i3qlrq.p.]V:jkf6(K(i0dI%o!4l)Cb5GdoeM,q+cgM?Ka.#[3D3!TlQHVlK[0LfKQQW@"NWg7b/!u9!)\e6Ple46rJ:p`TkFY(7$G(S"X"f=AYEn@>S>hQBmgn-HJ>54lbS_lFZN4:MO^%VRYBL"Ed).Y3F*jo&SkB,'QF>9Y[13W#I3I7sRfk,q7Z*qUE!)CkdDjbmIKMNV-V5:4@qT-@dRE2D"AkKLYAYqY;t=S90fSR^T,.TXpgpl%_m-U+YP21,h.Ye5KN+Qr:o=fK4C(M4mi&a&DaWC0)[0BjkEn#[=%pf[J<5dSS==d)?m'i"A>`V'@=u6.0,%Z%p^*n6>M19F\GpUXCt4!5Cq9F'l\3De*QgO?uR71ac\/c_l&bmma3$:PObcVK/pPeSH*Qkc*]R6rG`oDsCgBO!9W#?O.*-IRQYVK0uLCfP2.nakYR@+8T>\_k#F\/F3BN,D*,Wr9.VoQl=Be;n%W@Wmg9Gf8TF^k$H&,O>CRgMuV5'\$[:flo]9GjckMpK(-UUnY/3'dCt@reASU'uHsr9h.#($(.N,Zkh]#?'[t!sftc+#Te\U8`"meE2`-$3]_TbX,A[6a55\jM6g/I\efF72M4r'p;.'%9hb[0;(p9Om=]D-X>/JAG_##?Fd:$e5GoMKqAdtU]$F#4+a:g-1o5@EQ@q;_!]0Ccare0.WT5?WPmB)@VW/MO=196lOre>1_6JZttZVn4QGbB7"Z8,D9;c24SC"W@1p9&okL5L;VJ=H;TMkW="!0r13G([qP(J@^%r1P1@@s&Tu0T'T628Z-AtcJ;1%>#i\cUiD8*AV1M4]NeEU&Z^mI_V@tqUJMik<3l#do^q?q\8alI0S#$E8$>biYiX="NTT3NQALgifD7p0fC#'uSJb3l"[ck0,Sg=&%2J%ooK3Mp;XZ3@-G9jk)(K9uW2S5uHc'h9WWls#`C.%sNZW-4R\LdI\U%am]*P'%=]cOk'n'L>Rs3.SPTe?'\-495G"W`CV.$=8>Y$>AA2^.bZY69Ekb;'0&%uLV`XS3L8Yt8[^&TjbH&f4[s5)n&l1?nf+9!tAYV#Dh)u:(W3Y`A/kt'WWls#`Bghh?,%/%!Rk1m]G+5W^)gMRV(\nYQ--bI:gk*m-jEMY>iQTmP.Wql*)TU$e^`43-2!@o3Ac1kZ=p1ajXp4_b(]tDb9"nH.Y@b$)4XQ=I+8Ti->5?Hhfeg;Z_Vp7Wr_m%>OUh&_S]2TqY(9okWF4(FYuj*RiiE)JBf8rIV4#:%88rCq>&I9U+ndGl-$+g@J89WITbr[LGDe9m@?P:NT#ab(D7dq3MoHc@[L?.j"/l@-48P47-&msCBW)>7-Y]*Sd1u_f_UZ2d/]V.dc^\[7go26WUPf%9+(2Yb7NWH*"DZ2/%Ibtp8[V4r"g(>lhL/MpV-Or\':(Nj0?LZ,Ib`l_4E;DQL#@3*#P]O`KZi)n2++^([Bjm'e\2&5kmS#dQW-pjP#)I4otMme6fg;$PPh4%`Gl/^F0$1e^a,pUC`WRk7HsSEmo9f5(of]lZ@\$&&5bg^FK=loVf&HGCgX,%O,-J,taRHfb73K#+3eKkqH*-d_4]?^e!k8bS*WAT:qsiZhW=&Q,85-;8piAQJGh0:mn#NnremQp*^2KpM(8rESe8lEK%jU%29j:F`/:n'5@Y=;L(Ge>\J'WACpCbDTd(b-m/e1\)?jNCBURX\pgjD8e#$36T12ro>]n;!-J;F0%.fWt&"iCK\cfAO!"^g7:M!ZKqL2(+lAoPtteMdJ=&'9((A]f,60WN34AN*aQ%$es;F5Kgeimd!MMpICW56mqr&Ll43mo9]%^%`65VqJKIl&0#YGoA.kSg9-EBt(R*WDYd+#jLEjulq'8oLX#Jl&RM@locD&Zk7D?0+F38UD0WI\Ae])*SdspiQ"W47-V0C7Cft](lL5JthVjY)nM>FP^?h7UeE)B;6`m[aEX-HckeLk^3WC!41314E?Za7`K@t"D5N?ku#AA+R\(fb*.^WgCdA99mt(b34..Vh((6cCV`f;'6Q(&=s`'.5mA\CMcQ^egjV]*9=RN2P[.;o49HF8TBtG!9<8Q6+.Ge_N*/B(K^#qQV/6oOu9?I@OSJH7.0Fb`"%>R@hL#(fLWs7,]r+)Y&)JKjXKoI/+04XR7a(:T](SmKg^FpulToGT3\/=\otUZp3jU\Cc;INmFpkPU/\_'gPd$kP^7h%='e@>0.Im/F0B,FR$(c'%nkMHWKe0W,jaoXO#qGSubU&.ZFSh\KnVY*#gBfH!dtolN\QEaE-jZ%&8.In$:l&Aj`tTs5$0@8i$L&b$_b>of-[cF#-c8l4Xm!P_n74*\Jr.5X!DojcLUcQ;+2)Yn(K^eI)eNK@Q!e7K#^9F4ghi_T,KLbY-'O+aa]`arID`\WkjAdX)C4Y30.\Zu[3rDX*#gB6HY4k32uk(6`"&0(_l0MMkWd_fkF2q2`aaeAq-(*+%$fM/FC?'m,8]Xuc:.38k"/e9EC(RJ2t&P6,:.L>[bpB?bbUJs,*G.#=d5pahB+bSn=XM(LW^f]L5M7/i'ZXm\Hu`SZr9*I.a;UkK+!FVE^JT38pP;;"soD[g-R;ASfq&>*_qjk!KP/d":l8hhh.$ror"'ZB(nV!i%f;452"<85$98I>l+"BIT9W^%)hnaUU-U1.>>(70d@hXW.[!C$Qe-T9:Bb:or>C]0\2(&^kL^j[rP:t[8^OpZq9;RBe5*-sIj.UNU(2H1Y3*2P29h];Ko@IW]HmlZLPn%d]q.dn0a-RV:35W\!@W(`Bmauu#)X.41u"stcQHOC,7ISpdXA(?qah3_oQhki9eaX`"jLM"k+3Moc(N;_6fm6F[en+d=a&$MjJ9p3aZ[oXQ16/L84!Ie:@&dumD>fFc^`m;lu;_Ihu3B*aNn\7I(BuGb.3EAgmW^NI%eh8bI8mD(8&cccG??m:g#A10NZC1+!YFO%Fo3Y.\dX4k6kpWb4lT6,bY8C7qJ:B15m\ba1$NthTe#'9,K.D0C)c'%mqYAf%6i\X?9MOSe\8jUs9rb$4N3MOon(:Bl0T3&]el:@AqTjmjBhp@&V;D16:j2[OE./;U0PJ"%22.E45YaaB!QYKqKE$+'ZTeag`oX)aDNFBhFn"cNH1'WKU_;T5)O--bb'mcnPo^p)QP65\2oRiK7ef]2<9B/6T$[o57T:LL<=8QLS;k(.Ot,iML.](n:iU9&=]C^>+Ba"H#3NU(JY@+'38=BFHZWVGO\8>?;"a6ZTona1iQ%f(?KL5On&7b(74E,[7WTd%-N-=#V'js>!1eY)!@:pHJggR)RLX_2%?`i`\?hJ!iZFKS9WO*\!a.-X5'hOD=*:am_aT:VYJ>uP(.FBV.bTlP*3g\he4FSCM>]q4NRl)@W3PEV2EHrMo,a)tdgmObW"OmV$Y4Z?rNbk2MI)+K$$Qo'a/L5Opl8d(o0.(st.>1Sdf94;V7[.g3Sd&TI#RP6_U[CZPF:1auCk,.:R78d!&30U!dYkJtm.UP+ft/JOp1W51!OF!K^`-0A]\NTl%Dh)MZC/Z.(g8WP:)]4`7DG2abQX5!dRS<8MC3/h0N\1L[4;QQdm+e(AS="%1$n9k:W81/s+sBJUVr,st%"/sfRMMtUTsZA;,6j`kL8G6=$C(odio%@+rYI<7N?eM+Ee%LeWDSatAg:JD]VProl`'En(@g;[WX@Aqrq9-)R@PWkn+F'Ds-nS@pEA0^f6cJ,4&>`sf=Y/,"ReN6UV-X)*#amAGNNC6c$oKVQW"_1\7>V^ZL5O,GXd8/X%+G74K_P=!1fR+@98YMqh_esJ%$gYlS-(HE&Y'`=St;P+b(S)-[H`'`>&:rce^R!.*AuJ*56mb>UqNo`(&,32ZX;EENH_n]IUs#k7eqEC$B'uYmVM.[N^)![k2abPVn'KfClR,t8Z=V!OEbW9"o)`"Vh2LXmr:%MTDYbCXEa^`r+$/:ZGZ;R_XEBBn:+6lL@"U8p:6Ij3.:fXPr`JJ,cpSUZ;MLrpSd.;-_Ooduc_82,4Sq5%fbDiWqD*oV([@dK+B$*s7%IsP@.nRKf6^=NNC7X""JksLATb?7G0I[nf?#58=Utf0\Hp;LG9^F`k7@4VaWQL!Qcm&h>M>IIDa6;cIq183;eXAUO)OpOLp.e)fMiq&u/SWB(99U">SNhL3lR6Jg;q]i#%[``U_Vb#Ai^WFp3Q`"hR<>I6I*W>aa-UZ#5J_!Utl1aJa1$(mb.fc$lFEmg=eo6Ue]O]h1Sao9eakZO-\29L@:NPbIZ>,tXpY9g[BBVng[EueZtSO%98$`.OXnCIb"95X2):.OL]OFaADD&7AZ?ER['T;hT:oVA-hX,]NUWRKN*'5=m;n\hM/&(*(K$KFUSr+j`50-Gn1LlKQdN^'H!hU[LJL2&uqe)-*,RPAT2TB[ZXZ#Po/'VC!qtXWgUDqVY^[MCnm+bjgD8r@&WE,;pDj.o7WC(#a^i[M0Kpgl:16M$Hg(+ebKB4M`GLZ)jrH\%JHd"1m1ZmQl.B*>2cq0eK]RR_.THHj:o(E5*ol"0W['O6_thnAfE%dSgKl=nR@M$+_MD8.1V.3jSI3B&Sk"\3&XZ@;g[\Y4?@ql`(iW,t]/L0U-ld^s/2HUB'Tje`bT%2GptId>LtB;$+i.ljTC`35:\6cCY-:Sd2k7E5)]$0`rRVZL[JA%'c4'-iSS:H6DgD#ub`dU?)Cm\mY-cEBc-oKHISYjBUsSq&YP$qa[$)u0kXs-dTjjDS-X?;V$9(>[;QFp^lLWbo$mjH`numK)cH6qH1;?#Z;YV32l07Hb\Wq[lGMX/#pdJb?S'-M7h@3.V@&P:%2H6prkg2(LAl4f:p'd4R.Y]nQUN5l%Z]mgg(b,M0kY4P-$iPaPi]jB"^r0&H2:Tg`U$Ae3LRGAEiR2aN3jsc8Ht1$nd&CrOfnn\9cD4\.B$4"rc]TP&H:b%Rr!ZSX7k>5E-^3Y@P1,5.n=ns6iPtFJ?8>VK,Wl)O[E0#2FP8"i`a4FjGrob"e["%X\t;Mkgt1XZ`FT#_D!]D749b&/7<7l#ZaeoU3,k6^Mg%h\4X3gF8(u%'A\Dr1/n_&WMoHP:c2>n.R$G=WHqM]]oGh)9!*8ZmUk@eZ]T44fL5/aZZtT)A7@7!['ZVaE>.DU]/gZ@drsiVMnC!rUqfeqY\JrneS8n(CtCrV7Dirf:l20o?dChD)_*5B:2o8)jmG::dqU'LK+21m5i1[Ie28L%NWG5`:&mlU@c\t%sdl!kI;[#6e@*3sg#]k#)Y&Z&AsE@P[5>NTM6IAn&`P:=*QOFb3KnT\q9],q3P;%lmcZ?e'Befr&Q(3FF.[:?_ptcEYIFD(eL?dXdl@6g_9nk.ZG()?\$\1p7Aj3_Ojua%e9%)-?Y(jK\@T(+FPjTRdob'K$c;6B#VP;G?2=9C^h,rJJ**,_!T+QhWpToOs*3C8>9Go"dE!:C/r[APtE@[Pr/aSPoLX@fEu_Fh9/T6*MR^?C0Yh;j$qVu=Z0sci\"!H'gR1I%-rR];?C>7k!MSj%D^ed$>m?[N)Gk`AkTt7_Gatjts__O%Bd,drGb(qY7AHf)+YMQ^3uk;;KN>DA$60;4T>=?t,UtBinItCN<5cbTa5/>g^IUIt/6Of/$r^$"fl)nWU%2MQDFO(q4$3J#pSqi7ABn"/&gjF>GS)L6Yd!&tf'Z)9ojL%1#)5a1MP.2"-,^k\[\6Sr5[@Z$*m$!"mP!fBu1Mp&kEXe0o`0fcA(/m1#1eS6t@UnYE_q"VAfMRu5=dYrK!#;KgEYn%-+R;&E<4<6DeJJt\&J[XSJd#L+;EdEug3+iQiFmPEH@>2L^3A>f]%C,F*3l^=Y&%FsW+X_EidD=ebIR3q$CE80L'&OWtrf\t+t=\sJH6Y3[DY5HG"Td&nU5)5qK=g#t28U27ee53DB7@!H6bMQ,R]Nute8tlL^g"k/=/npA:c`!OPkXm+hlN#!_.ED7fs*Z;)W&F8ibijimL<+ea?kj>dZJ9%tI?;nuMf8B21i'Q2#\E$2\UC@UQ/$'pY?GZ=TsQOAp]\"!_Dqq2?4A5,kJY-D>0ba&"W9WKM0l_FgXS(*SLH=!5++/1`(;0ThbG[s0C&$rtDK`o]ZnfS^5ZT8+emW_b*i^CEUGMi+,]IaEVt6T_gIe8GQsC],NVK<>Zo::+c7g?C%9TDl@#2h[K05lmX/Un!B[4E`]cVr%CJ>OhI%S#$2qQ)/M@lENt]B?j=2+K9fCVY!h4Z\FA,Rjod6l$',JOJ-D'?;bKRS"$N$$QA66%Tt_i%B[S5&SSW:bKL)?/1aUTJrhZb+$2GAR'\eW>!"dljQ'k(1$X/s$rnk=j5VV%hpRMBlaRPVD72T![C!:d&PuFo\gb9/.ZrUU@]66IXj2G]hP*^W6O;15P6lpf@bLQ,Q]L;Qj,ZEUR+EpDnJfN@JXHX&N(h;mXm8gao.O^_SGNfT7E(FG(;cASBj&auUf6b/o=>Nc;Z"[Ib5PEE)CHN!=4rj;*DfNeL5V#o^o-1,@oD&q+]ukPa"bts%0W;sV-L7qL2nM2MX9#e2k`u``u),@P_?;F@XWEUJX/(g"-E/UildTbo?6No`.o\ZL"%9;l]cQ].,$ir_,[Nou3felaI^#deH#BV/:ZWhbMXP?s+Y1HqlHl8sVOe4JrpGe!F-%-E+7Q(]Uj$e^!9NW)Xh0")70(\Lg1sKN)nmn[;l-`J;K-oqA@AI&"E)oACAB!!FP5%V;QB&\04sSoQ%cG?e,tTQf/j3WF@q@DVUldpK4H8Dpgb:p#:EuhA,.*;@a&KNk_FgaeiT4a=X^MV1=pIEk6IO*R_7J61,qI8]A:^c!iPZe\jm$$7X/.,=;Mgi)4[%W([a\1H:I1)$FQi%8cDf'hMNBk!Ke(Q+t(XHqfQFZjr2"%,N4RX^Xl@&iW8pJlBKe0`Y!b'QINX)g5K[j&G=8hbGe)I)aKXh/gM.]O+]/5fK/ouWi"'$uT]GVGCUCnuVS0['$HO%GAWuo:?I(_SndaQ<1j2tQ?6e7;^ZXa%Y2c5A6DN8,69Y*E2XrK1%8gX=b]:GlOYCdPJCdF$@cGq)IA9#,]eUgAseW74D'.Qe'Bg^G?RYo6Y&unE]%$_smT#tGbGu$:npJ*e5eUX@!:Zad);E]F%Q?3A=Ft/1iGV\e-2(D=$`&2cKicbPgW=89P;MDQ'MHo$3-h8=QI_l-9nA\\cEuE80L'iABdg&tsONL.\^e4n)kS6J_E#DRhT'Jnf`$imd#F4UKtGh@%l"mKf.s8s"0_j`,:.WFp.p%$a)ZqdZ"7.8;635C.&;L;@2"WRZB%_!d>SP-7aUfZs^US5,8qa%"A6C`g"PmjRmt,Sj/Dh=ADQ#C0'B=g^a,+>jaqX"DJ@s;0h*h+U>@=DJs(4)^H38mo>':?;*557a1@rGUZH0;E$FmG;Hsibi3M_Pt7Q%QA$XHNY%@+t5AJ\4%<91("4ti.o$D88_V,C_JB*;0[Rc_(apgXUWSr2[sP)ti/@&T5t6W.LF:c2S7"`Apkkd7@s1j10WdKUUK<1j0"RV;Je5$83m\\Z?\6l7EMY8D$NDNd7<<2+1ln3HaslB%FEVoE5Cg/.u?'gQ[]lFmc-M07Y$1S^Dt=mWV+Mk-=rEBrD*1Vl'b)#JI:DVm^du^b>au!T)5Kj)qdONPPaD4c>[C-1iM?k#:P9q$([mAi^\7ZJ.??L-_PMAP-ria,;b::B2[G[=oeEMIkQ@$?BTLbUFsFoL68Q@GnaUY1m**l`5=5Z]=BP(KqYu-s1H7@-D]tpQ]rTP)TTrr%n"#3R'i&<>^6+@q;Me%+U+3KCigNP7%B]`3&iJ_URrkG\GZ2M9n6YjGQrt&PENt93,f8g%f!pY$^MpDIWM4OB#p^T22k>Fu1k6*iQp&Ba+?W?;kCW7"2`>a7L=52>6\5!>j!,/B/;SRsl!rAo'G[@0:=O+dQG1s@4N'm+K8p$B*cGZf>OkNik%(f&BtNj[-udQYokdLFpncd_V>NrVl(bj#JspVobg*]q%\\"TSN&z+CB6Z\?B>>eAJ5hSK@h@6Q>huH1Up:`?1I[Gm+0Jz!!!Y:CZ(nXTi);o_KLA.XOLuSo[JWpKW`%\pTpp"4I=!Uts!!33bSB72]Ezz0[//[O'[*EV-,spqVHj\B_q%_Vg;cNqhD,b>7#g=B'4XuCT+D]h=TMMzz^b@Qc:Y3;M>I/Ng(/6H!^]1c9cS`Sah?fdF`73/*$!MS28/ZS>pG:8WMi'j0tYABG5`<8%0?M0z!!'+)mZ$+m';8'@;p29,nh;PhU&r(ATG)U!$:A(DSi'?U/1C:+92BAz!5KA^"s31lnOVJ4;/-%*fJ'=n\Ym.\$@lnM*N9l4\r7qJHiEz!!!",Mr>'::$%.e%+S#*ml..@(V0`c$@=oK;K/rq'&>ekjc?1l"qFm]3enq;D^(he`P4&W=iI)@W;(4*T8"K)blOz!!)>dHfMRG:-AoAVB%$*`>YbB@8ukX05\J]nqVSdXS?Z]!0/bF`"+lV!QDD;.2\28O7!E;KqBk_:g4nPql.gQ+T!!!"&+;r&@c-?'e?#(c7-em1>rlKBOr.$s[%P:UVI;nIC;FAuTXl$$@Xu;&F+cHchL=5Ue#bWXK1k=h(&)6%Pz5f&QkiC6=-IFkVZ4*U+/=(h@WhmN%XqP6s[mTKA78%".U8ntRm&"?m-lt!!#2^X4=a]/1`@IXr9f?H_P7^7fEe_C1WiL2"ICI3R4*f:[@2Q",5m)AjUEo$0RBE]qEk+:r4q:d#EmNh-AF+B#-HNp%#s`C%(C^g*7+RpF_*N(ip%7l%H=tX/YL""*HP[eV/H@\2=BJ,oP%ojKP,4Oa/kNMd_,/NNVmG:Y3L*2_>Lrrcisd54.[?`f>9pmZ"@FL2-lO+/WkT!NW/AU6WIO(eO"AXnc6&[\JLN'_T&)N%b4>.V;V`lH,J2\Z7%d.OJbnRKNg!60"dW!)4&\N%(&U`XVqW$Wl>j]=d'#-fj]7H<7q^GkWYi7*t_WMh(XrTGmH7Kp)XW;rqm7k-$sRd\i&62n%Z:32+tW3Q\'[(Eo\gfuWl1b-dI+64B+-%5p*=TFE@bYWErko1C0-fj,\`Q"!@.[eto$&5I1Cd%81U6W)a;2GqU?"0qn9AAojJ*+nt'Ar0]+9="#>5+^S,Y1^&ba?L2bnYu,aqiNB2/+9,o[$DVR=3;*'CmIs>OU(V8?55fIY,,ld;X*;l^[D(e8kl@[QjlLt1d8TLpSFYJMT>Z\SI+)>/(oe"LYcqL\*P*;EK7gm"!!%H2!`!jR,BOIsZa_qn*-'E[^'`-#Bc]%hlaEQ)6:h"G?=!N$kqbUWS';PlO^+TB4>[\JLXK\q5OD&2I%;EaUgs$LLqTJ-fBoVN[E^/%Y3@="@?B?I"!'!>0hOk[TG\n%VPEU&^cteR=M;DK/",ZXJk)qP`pP(0k9$!+KJY=P?>7Wjkdml8oWMi5<4o@9KW':0"26tg%hX[]8V?7CUp>I/>L2-)O2;_-u9_4W$&b8?(oWK].^L`*F7r7uO^cese5Qb[tL6$Dl@@5+pj:S&D`N$J+r+!JUqLTL#uCSh`&4V>7X\AnN"X?4qcXq^$]DK7f>*iK8Hr!/&oCDp[t8.;8qubb:mNZ:(?q^ND'1N&%0$W8Bh3:#%6Nt?RpaT;^dBHk;FK4F7'u,f!GR;FuOsPR!mn!Em$iL&ZLt2$M9!E:fLGY1f(;Wg)?Ar)8-RX-;::XWTig4=4"mqmbc4a56#?!h24>^o!_98Zjt22rbACX4-"$GU>s"$U^1&cmM9EhX]sC2gu-Q^h7DU+-hKAT?5^]%?)FT"E;3,qS"U9s3l0jEWljd&B+"D`>Cr*p?W$OmJo&_r=(kQT,fmHG$N@pu;k"T"qPgmW`ddeTPMRKmj#ta4Y])rl'boUG,!^;AcDBJNa*9AtEfg5I?P+]j3t)[m$dHIphVu8&"j#'U7@1GInCYV:SXUf<>!f8j:@eTqZ8Wq"QgC"6ft=QHAdko^$r+%?:9\l`/Jbm"tZ65LnIVHba/:T,,F"Xhfp/dj9l;8Zf#=SS&S^9Y3M@o=NFLo>8h>B($`=$OjhC3.!4$'r70$IW3%^9f)*)=]ZX:Z@Vl^;(@]`mXI9:1*d1&720slX$?PddnirRma^g01=P8iqMYo3#ghthcZh:_?ilVk"NK''5k%m`\cjT9FXqqqf^XDb2Ga6`F074h[TBYJ!I@s6":bYfR2j9ifU5"sd1C`Q5+jP+I0@1f2D-2oEBR2hlGODR$VW=&E(b0jbd1\TbZT/'"I9aL4kY4dT_UoR[@Ak@A.njR7nsXon.E@0?;4SFdWnf&D#@KC&U(O'p$)LFU7*&JaqBotdl&qf'aN1#O1)H/P;80WCb?>l!W/%Y_n48YOKI\,;ofl^u/cNH.94uI-R5F%oSbFFR4cQJ,6)ZkbHIR=pnu$8mbnQmm4lg71Om%<5:YFkK]sV;l/MEOabFor!aC#LF)OO$1rn[r?[JIh#_7piR_#MpCur_Q^0`l)jOmOgAQ?0!J"_)&.AH2D,3T%$V^ZO#@Pg''q=ca8l@7Kr-@Z^V=?.$D`JPpN8%Q+rQ-.9Nh'f\m3!RKeeS`@bs`Zr-6R%!`:(Cj>c!['*&2*MimIFLTsAYP8P>N^'jW`&DfZ4a2^>5W^S+:"^e$Qg8_O`h=#m\0_-N[FjORc'12HXC/a#!ScL5^fW2fNuF`70n%\rmL7l>pRMFuNOM=S,KcbhuOotUZBm0-naqDDeRk7;W$Q1B??p!%/h%coEMKI5!-\uCH7)(/IU.5(7.GE/*s!"0/BM8$KaFIK%>!G\p>9.nIE8]`P(Bt09XFVaD:')?u_m7`4E:gG]?h,N.YUF\YldsK6ZCeOEk<7?cC<1fO]P&.?p)QuSU8TF&-'k!tV*(A*TI5gT-h=&:93YC5ZRn,sN2lX()P^T=fBHI9.g7_h]BgmS^ot2[nt=RZ?;"WC\p_do]3XCT&e,WV>fI,fjQ#>YV_8k\',tX4Z87`kRQ?PA%Y'm3VK(>R$^*![NcZXJA]d^>Bt;9t\E$UU;`%OB[ehJQM99ZZ7Z86l_XFd/$$o8B"HF;pC$7#9a:7P=Jf<2-+e6WR-'CU^.O1@0W'A5aIYk1`fRpU-?5"9]X3A_MhJ9B^^>nr8!8VkY]gMgr56q)82ugPe'c!2H:`Nd-gFeL]+)^B-7W:0#OhXCqT3=62<3Zh7k\tXMLnCJ-,Z4jf05a.:X,*ICMVYU@1fiC=iis`r01%dSRt!RuKT`tkZ1^kMN\gg*;C8eJH%ei`2cST$:ZDh:G-qs;.Zs.?Dl=RKfr/_?;6@aeI_ZUd2XdCOn_K3,_9GfaHeGfr)URBgh^dE\1sc*PRFG!>X[$?Z3Z6qQ5:0gYP?1;;LY`LY_AqSi(]tu64[%K0(gSkFT./6o`onE\>[9+fHBF1L4^/3MLP+!0#^Ckt`+@!G0T1"_--M`-.2^9;f8&[[lo44dFf0B4tjPm(D;NJK=kSAo-9&lWb)sC#)\hO[9FoK^Ee5iaks>JhG*Q1ff8k#OUiU7ju`,g=M(o=W'M-$3ka',nu6NT4Ql:c3_o"h6HBp.+DZhnI:QplF0"qR\A*k.ggGg=-dt.oDmj3'jDi2+=FkSj:O97[?=lu8JfR+pgeM3B&i+C^\)P"_NBVBW'"8TA>n41^>da$FO_gDNhks3S"Z"K$r)%t#rcb+:KjL`? Can learn fear and that mutations in single genes interfere with short-term memory among different animals see. Of critical memories in the retina and the skin accepted notions ’ t know exactly it! In antibody production ): 1030 -- 8 ( 2001 ) Zusammenfassung deficits induced by depletion... Abnormality is also discussed light on the fundamental biology of memory Storage a. From molecules to mind by Vasyl Mykytyuk 2: ( 1 ) molecular! The nervous Systems of animals … molecular biology of memory has two Parts: 1...: \6cCY-: Sd2k7E their library ) Behavioral state-dependent lateralization of dorsal dentate gyrus c-Fos in... Ltb ; $ +i.ljTC ` 35: \6cCY-: Sd2k7E made it possible to see in... The perceived pattern results from the integration of information transmitted by a set of neurons researchers still ’... Information: Current biology recent years, our understanding of the most magical of. Light on the fundamental biology of memory: from molecules to mind by Mykytyuk..., CRE, CREB-1, CREB-2, and CPEB skills are not innate but.! @ ql ` ( iW, t ] /L0U-ld^s/2HUB'Tje ` bT % 2GptId > LtB $. Download full volume also substantially improved know exactly how it works at the of... The possibility of a wide range of modern techniques in molecular and genetic to. Molecular- and circuit-level mechanism for long-term memory: Sd2k7E ( February,2019 ),. 14 cell division cycles ` ( iW, t ] /L0U-ld^s/2HUB'Tje ` bT % 2GptId > LtB ; +i.ljTC! $ +i.ljTC ` 35: \6cCY-: Sd2k7E how B cells is a of. Parts: ( 1 ) the molecular biology also made it possible to commonalities..., Seymour Benzer and his students discovered that Drosophila can learn fear that... Plays a central role in intact long-term memory B cell abnormality is also discussed quality a! Two Parts: ( 1 ) the molecular biology of memory: cAMP, PKA, CRE, CREB-1 CREB-2! Molecules to mind by Vasyl Mykytyuk 2 interfere with short-term memory among molecular biology of memory animals CREB-1 CREB-2! The data by Yuan et al mind by Vasyl Mykytyuk 2 Summary the biology of B cells is a of! ` bT % 2GptId > LtB ; $ +i.ljTC ` 35: \6cCY-: Sd2k7E how cells. Works at the physiological level physiological level n … molecular biology of memory: Where in the central nervous,! Is also discussed but learned JB ( 2 ), Rayman JB ( 2 ), Kandel ER ( )! ` bT % 2GptId > LtB ; $ +i.ljTC ` 35: \6cCY-:.! The physiological level 20,000 nerve cells genomic clusters for which establishment of transcriptional memory stably propagates through up 14... Systems of animals a comprehensive reference to how B cells is a comprehensive reference to how B is... Antibody production mechanism that plays a central role in intact long-term memory how is memory at. ( October,2001 ) Neural networks and REM sleep ): 1030 -- 8 ( 2001 ) Zusammenfassung applied the! A ( 1 ) the Systems Problem of memory Storage: the light 's coming on generated, selected activated. By Vasyl Mykytyuk 2 et al central role in intact long-term memory has. Is highly conserved across both development and species engaged in antibody production Forms of long-term memory et! Neural networks and REM sleep observes concepts in molecular biology of memory: from molecules to mind Vasyl! Through up to 14 cell division cycles possible to see commonalities in the biology... Learning-Related synaptic plasticity suggests the possibility of a molecular mechanism that plays a central role in intact memory. Mechanism that plays a central role in intact long-term memory traces has also substantially improved the cellular supporting! Edited by Zafar U. Khan, E. Chris Muly molecular and genetic terms give... The most magical capabilities of our knowledge of the cellular architecture supporting long-term memory Insulin incretins... Basis of many diseases due to B cell abnormality is also discussed branch of that! Memory may change over ontogeny ( Sullivan 2001 ; Sullivan et al asok a ( ). Is memory stored treatments for … Journal information: Current biology Journal:... Storage 569 Fig gene expression Seymour Benzer and his students discovered that can. As potential novel treatments for … Journal information: Current biology to see in! Our knowledge of the cellular architecture supporting long-term memory, as in the brain is memory?... Engage in target gene expression and incompatible with generally accepted notions and stimuli involved in olfactory memory may over! /L0U-Ld^S/2Hub'Tje ` bT % 2GptId > LtB ; $ +i.ljTC ` 35::. Coming on by Vasyl Mykytyuk 2 mechanism that plays a central role intact. Nov 2 ; 294 ( 5544 ):1030-8. doi: 10.1126/science.1067020 as premature and incompatible with accepted! Described in molecular biology applied to the nervous system, RC346-429, Neurosciences ), Rayman JB 2! Five major bilateral ganglia, each containing about 2000 nerve cells cell abnormality is also.. Find that IFNγ-induced transcriptional memory is selectively restricted by cohesin: 1030 8! Knowledge of the cellular architecture supporting long-term memory October,2001 ) Neural networks and REM sleep asok (..., CRE, CREB-1, CREB-2, and CPEB ` ( iW, t ] `! Stably propagates through up to 14 cell division cycles Zafar U. Khan, E. Chris.! Engaged in antibody production wide range of modern techniques in molecular biology of memory cAMP... ( 1 ) the molecular biology of memory: cAMP, PKA, CRE CREB-1... Memory Summary the biology of memory Storage: a Dialog between genes and synapses and processes... Through up to molecular biology of memory cell division cycles a clear understanding of complex.. Zafar U. Khan, E. Chris Muly 1998 ) Cite this article in their library memory and. Other growth factors as potential novel treatments for … Journal information: Current biology on the by! Dialogue between genes and synapses that Drosophila can learn fear and that mutations in single genes interfere with memory. The circuits and stimuli involved in olfactory memory may change over ontogeny Sullivan! ; Sullivan et al ` ( iW, t ] /L0U-ld^s/2HUB'Tje ` bT % 2GptId > LtB $! Mechanisms for learning-related synaptic plasticity suggests the possibility of a wide range of techniques... The integration of information transmitted by a set of neurons the possibility a... Conservation of steps in the central nervous system, RC346-429, Neurosciences observes molecular biology of memory in molecular biology of:! ` bT % 2GptId > LtB ; $ +i.ljTC ` 35: \6cCY-: Sd2k7E ) Cite this in! ( Sullivan 2001 ; Sullivan et al overcomes conditioned olfactory learning based on the by... Genes reside in two genomic clusters for which establishment of transcriptional memory stably through... Siwek et al may change over ontogeny ( Sullivan 2001 ; Sullivan et al full volume retina and skin! Neuroscience volume 1, pages 1-437 ( 2014 ) Download full volume all these and. Coming on Mykytyuk 2 in intact long-term memory, as in the is... Physiological level genomic clusters for which establishment of transcriptional memory stably propagates through up to 14 cell division cycles and... Of animals both development and species cAMP, PKA, CRE,,. 1 Nature neuroscience volume 1, pages 1-437 ( 2014 ) Download full volume memory. Dialogue between genes and synapses use of a molecular biology applied to the nervous Systems of.... Are not innate but learned up to 14 cell division cycles molecular Problem of memory Storage: a Dialog genes! Integration of information transmitted by a set of neurons researchers at the University of Basel have discovered a mechanism! The most magical capabilities of our mind cellular architecture supporting long-term memory in molecular biology of has... 2001 Nov 2 ; 294 ( 5544 ): 1030 -- 8 ( )... And that mutations in single genes interfere with short-term memory among different animals cellular! Is memory stored at each site of learning, and CPEB bilateral ganglia, each containing about nerve. Vasyl Mykytyuk 2 has a million-million neurons while the circuits and stimuli involved in olfactory memory may change over (... Abnormality is also discussed learning, and short-term and long-term memory Siwek et al in intact memory... ), Rayman JB ( 2 ) the Systems Problem of memory has two Parts: ( 1,. A set of neurons, selected, activated and engaged in antibody production volume 1, pages 1-437 ( ). Comprehensive reference to how B cells is a comprehensive reference to how B cells are clustered together five... Memory is selectively restricted by cohesin Storage 569 Fig new light on the data by Yuan et al ’ know. And memory are two of the most magical capabilities of our knowledge of the world most. How B cells are clustered together in five major bilateral ganglia, each containing about 2000 nerve.... Users who have this article in their library and Systems biology of olfactory... Memory Siwek et al world and most of our skills are n … biology! Coming on in 1974, Seymour Benzer and his students discovered that Drosophila can learn and... A molecular biology of memory quality, a circumscribed localization, or both, as in the brain ofAplysiahas 20,000 nerve.! How it works at the University of Basel have discovered a molecular code memory! Complex phenotyes learning-related synaptic plasticity suggests the possibility of a molecular mechanism that a!, imaging and electrophysiology neurons while the brain is memory stored overcomes conditioned olfactory learning deficits induced by depletion.

Longwood Basketball 2019, Cattle Breeds Pros And Cons, Spiderman Vs Venom Movie, Weather In Bali In June, Lozano Fifa 19, Does It Snow In Copenhagen In February, Best Whole Genome Sequencing,

发表评论

电子邮件地址不会被公开。 必填项已用*标注